Our first international DEEP-DV research symposium was held between June 22 and June 24, 2022, in Cavtat, Croatia. Scientists from the DEEP-DV, FOR5200, and FOR2800 jointly invited international guests to exchange the latest knowledge on immune control and its evasion of nuclear DNA viruses. With a focus on system virology, the conference addressed various topics relevant to the gene expression manipulation of herpesviruses, papillomaviruses, polyomaviruses, and adenoviruses.