Publications

On this page you can find an overview of our publications.

Previous joint publications:

2022

Mai J,  Stubbe M, Hofmann S, Masser S, Dobner T, Boutell C, Groitl P, Schreiner S. PML alternative splice products differentially regulate HAdV productive infection. Microbiology Spectrum. 2022. Manuscript accepted.

Scherer M, Read C, Neusser G, Kranz C, Kuderna AK, Müller R, Full F, Wörz S, Reichel A, Schilling EM, Walther P, Stamminger TDual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies. eLife. Mar 2022. 11:e73006.
(» DOI: 10.7554/eLife.73006). PDF  

Caragliano E, Bonazza S, Frascaroli G, Tang J, Soh TK, Grünewald K, Bosse J, Brune W. Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication. Cell Rep. Mar 2022. 38(10):110469.                                                                                                                                                                                                                                   (» DOI: 10.1016/j.celrep.2022.110469). PDF

2021

Esmek FM, Erichlandwehr T, Mors DHB, Czech-Sioli M, Therre M, Günther T, Grundhoff A, Fischer N, Fernandez-Cuesta I. Real time, in-line optical mapping of single molecules of DNA. Biosensors and Bioelectronics: X. Dec 2021. 9(2021):100087.
(» DOI: org.10.1016/j.biosx.2021.100087). PDF

Zhu S, Stanslowsky N, Fernández-Trillo J, Mamo TM, Yu P, Kalmbach N, Ritter B, Eggenschwiler R, Ouwendijk WJD, Mzinza D, Tan L, Leffler A, Spohn M, Brown RJP, Kropp KA, Kaever V, Ha TC, Narayanan P, Grundhoff A, Förster R, Schambach A, Verjans GM, Schmidt M, Kispert A, Cantz T, Gomis A, Wegner F, Viejo-Borbolla A. Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2. Stem Cell Res. Oct 2021. 56:102535.
(» DOI: 10.1016/j.scr.2021.102535). PDF

Rink MR, Baptista MAP, Flomm FJ, Hennig T, Whisnant AW, Wolf N, Seibel J, Dölken L, Bosse JB. Concatemeric Broccoli reduces mRNA stability and induces aggregates. PLoS One. Aug 2021. 16(8):e0244166.
(» DOI: 10.1371/journal.pone.0244166). PDF

González-Pérez AC, Stempel M, Wyler E, Urban C, Piras A, Hennig T, Ganskih S, Wei Y, Heim A, Landthaler M, Pichlmair A, Dölken L, Munschauer M, Erhard F, Brinkmann MM. The zinc finger antiviral protein 1 ZAP restricts human cytomegalovirus and selectively binds and destabilises viral UL4/UL5 transcripts. mBio. May 2021. 12(3):e02683-20.
(» DOI: 10.1128/mBio.02683-20). PDF

Koyro TF, Kraus E, Lunemann S, Hölzemer A, Wulf S, Jung J, Fittje P, Henseling F, Körner C, Huber TB, Grundhoff A, Wiech T, Panzer U, Fischer N, Altfeld, M. Upregulation of HLA-F expression by BK polyomavirus infection induces immune recognition by KIR3DS1-positive natural killer cells. Kidney Int. May 2021. 99(5):1140-1148.
(» DOI: 10.1016/j.kint.2020.12.014). PDF

Jürges CS, Dölken L, Erhard F. Integrative transcription start site identification with iTiSS. Bioinformatics. Mar 2021. btab170.
(» DOI: 10.1093/bioinformatics/btab170). PDF

Wang X, Liu L, Whisnant AW, Hennig T, Djakovic L, Haque N, Bach C, Sandri-Goldin RM, Erhard F, Friedel CC, Dölken L, Shi Y. Mechanism and consequences of herpes simplex virus 1-mediated regulation of host mRNA alternative polyadenylation. PLoS Genet. Mar 2021. 17(3):e1009263.
(» DOI: 10.1371/journal.pgen.1009263). PDF

Friedel CC, Whisnant AW, Djakovic L, Rutkowski AJ, Friedl MS, Kluge M, Williamson JC, Sai S, Vidal RO, Sauer S, Hennig T, Grothey A, Milić A, Prusty BK, Lehner PJ, Matheson NJ, Erhard F, Dölken L. Dissecting Herpes Simplex Virus 1-Induced Host Shutoff at the RNA Level. J Virol. Jan 2021. 95(3):e01399-20.
(» DOI: 10.1128/JVI.01399-20). PDF

2020

Czech-Sioli M, Günther T, Therre M, Spohn M, Indenbirken D, Theiss J, Riethdorf S, Qi M, Alawi M, Wülbeck C, Fernandez-Cuesta I, Esmek F, Becker JC, Grundhoff A, Fischer N. High-resolution analysis of Merkel Cell Polyomavirus in Merkel Cell Carcinoma reveals distinct integration patterns and suggests NHEJ and MMBIR as underlying mechanisms. PLoS Pathog. Aug 2020. 16(8):e1008562.
(» DOI: 10.1371/journal.ppat.1008562). PDF

Whisnant AW, Jürges CS, Hennig T, Wyler E, Prusty B, Rutkowski AJ, L’hernault A, Djakovic L, Göbel M, Döring K, Menegatti J, Antrobus R, Matheson NJ, Künzig FWH, Mastrobuoni G, Bielow C, Kempa S, Liang C, Dandekar T, Zimmer R, Landthaler M, Grässer F, Lehner PJ, Friedel CC, Erhard F, Dölken L. Integrative functional genomics decodes herpes simplex virus 1. Nat Commun. Apr 2020. 11(1):2038.
(» DOI: 10.1038/s41467-020-15992-5). PDF

Siebels S, Czech-Sioli M, Spohn M, Schmidt C, Theiss J, Indenbirken D, Günther T, Grundhoff A, Fischer N. Merkel cell polyomavirus DNA replication induces senescence in human dermal fibroblasts in a Kap1/Trim28-dependent manner. mBio. Mar 2020. 11(2):e00142-20.
(» DOI: 10.1128/mBio.00142-20). PDF

Czech-Sioli M, Siebels S, Radau S, Zahedi RP, Schmidt C, Dobner T, Grundhoff A, Fischer N. The Ubiquitin-specific Protease Usp7, a novel Merkel cell polyomavirus Large T-Antigen interaction partner, modulates viral DNA replication. J Virol. Feb 2020. 94(5):e01638-19.
(» DOI: 10.1128/JVI.01638-19). PDF

Wang X, Hennig T, Whisnant AW, Erhard F, Prusty BK, Friedel CC, Forouzmand E, Hu W, Erber L, Chen Y, Sandri-Goldin RM, Dölken L, Shi Y. Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27. Nat Commun. Jan 2020. 11(1):293.
(» DOI: 10.1038/s41467-019-14109-x). PDF

2019

Wyler E, Franke V, Menegatti J, Kocks C, Boltengagen A, Praktiknjo S, Walch-Rückheim B, Bosse JB, Rajewsky N, Grässer F, Akalin A , Landthaler M. Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program. Nat Commun. Oct 2019. 10(1):4878.
(» DOI: 10.1038/s41467-019-12894-z). PDF

Erhard F, Baptista MAP, Krammer T, Hennig T, Lange M, Arampatzi P, Jürges CS, Theis FJ, Saliba AE, Dölken L. scSLAM-seq reveals core features of transcription dynamics in single cells. Nature. Jul 2019. 571(7765):419-423.
(» DOI: 10.1038/s41586-019-1369-y). PDF

2018

Jürges C, Dölken L, Erhard F. Dissecting newly transcribed and old RNA using GRAND-SLAM. Bioinformatics. Jul 2018. 34(13):i218-i226.
(» DOI: 10.1093/bioinformatics/bty256). PDF

Reichel A, Stilp AC, Scherer M, Reuter N, Lukassen S, Kasmapour B, Schreiner S, Cicin-Sain L, Winterpacht A, Stamminger T. Chromatin-Remodeling Factor SPOC1 Acts as a Cellular Restriction Factor against Human Cytomegalovirus by Repressing the Major Immediate Early Promoter. J Virol. Jun 2018. 92(14):e00342-18.
(» DOI: 10.1128/JVI.00342-18). PDF

Hennig T, Michalski M, Rutkowski AJ, Djakovic L, Whisnant AW, Friedl MS, Jha BA, Baptista MAP, L’Hernault A, Erhard F, Dölken L, Friedel CC. HSV-1-induced disruption of transcription termination resembles a cellular stress response but selectively increases chromatin accessibility downstream of genes. PLoS Pathog. Mar 2018. 14(3):e1006954.
(» DOI: 10.1371/journal.ppat.1006954). PDF

2017

Buch A, Müller O, Ivanova L, Döhner K, Bialy D, Bosse JB, Pohlmann A, Binz A, Hegemann M, Nagel CH, Koltzenburg M, Viejo-Borbolla A, Rosenhahn B, Bauerfeind R, Sodeik B. Inner tegument proteins of Herpes Simplex Virus are sufficient for intracellular capsid motility in neurons but not for axonal targeting. PLoS Pathog. Dec 2017. 13(12):e1006813.
(» DOI:10.1371/journal.ppat.1006813). PDF

Wyler E, Menegatti J, Franke V, Kocks C, Boltengagen A, Hennig T, Theil K, Rutkowski A, Ferrai C, Baer L, Kermas L, Friedel C, Rajewsky N, Akalin A, Dölken L, Grässer F, Landthaler M. Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection. Genome Biol. Oct 2017. 18(1):209.
(» DOI: 10.1186/s13059-017-1329-5). PDF

González-Motos V, Jürgens C, Ritter B, Kropp KA, Durán V, Larsen O, Binz A, Ouwendijk WJD, Lenac Rovis T, Jonjic S, Verjans GM, Sodeik B, Krey T, Bauerfeind R, Schulz TF, Kaufer BB, Kalinke U, Proudfoot AEI, Rosenkilde MM, Viejo-Borbolla A. Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration. PloS Pathog. May 2017. 13(5):e1006346.
(» DOI: 10.1371/journal.ppat.1006346). PDF

2016

Neumann F, Czech-Sioli M, Dobner T, Grundhoff A, Schreiner S, Fischer N. Replication of Merkel cell polyomavirus induces reorganization of promyelocytic leukemia nuclear bodies. J Gen Virol. Nov 2016. 97(11):2926-2938.
(» DOI: 10.1099/jgv.0.000593). PDF

2015

Theiss JM, Günther T, Alawi M, Neumann F, Tessmer U, Fischer N, Grundhoff A. A comprehensive analysis of replicating Merkel Cell Polyomavirus genomes delineates the viral transcription program and suggests a role for mcv-miR-M1 in episomal persistence. PLoS Pathog. Jul 2015. 11(7):e1004974.
(» DOI: 10.1371/journal.ppat.1004974). PDF

Murakawa Y, Hinz M, Mothes J, Schuetz A, Uhl M, Wyler E, Yasuda T, Mastrobuoni G, Friedel CC, Dölken L, Kempa S, Schmidt-Supprian M, Blüthgen N, Backofen R, Heinemann U, Wolf J, Scheidereit C, Landthaler M. RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kappa B pathway. Nat Commun. Jul 2015. 6:7367.
(» DOI: 10.1038/ncomms8367). PDF

Rutkowski AJ, Erhard F, L’Hernault A, Bonfert T, Schilhabel M, Crump C, Rosenstiel P, Efstathiou S, Zimmer R, Friedel CC, Dölken L. Widespread disruption of host transcription termination in HSV-1 infection. Nat Commun. May 2015. 6:7126.
(» DOI: 10.1038/ncomms8126). PDF

2014

Günther T, Schreiner S, Dobner T, Tessmer U, Grundhoff A. Influence of ND10 components on epigenetic determinants of early KSHV latency establishment. PLoS Pathog. Jul 2014. 10(7):e1004274.
(» DOI: 10.1371/journal.ppat.1004274). PDF

Borchert S, Czech-Sioli M, Neumann F, Schmidt C, Wimmer P, Dobner T, Grundhoff A, Fischer N. High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens. J Virol. Mar 2014. 88(6):3144-60.
(» DOI: 10.1128/JVI.02916-13). PDF

2012

Marcinowski L, Lidschreiber M, Windhager L, Rieder M, Bosse JB, Rädle B, Bonfert T, Györy I, de Graaf M, Prazeres da Costa O, Rosenstiel P, Friedel CC, Zimmer R, Ruzsics Z, Dölken L. Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection. PLoS Pathog. Sep 2012. 8(9):e1002908.
(» DOI: 10.1371/journal.ppat.1002908). PDF

2010

Dölken L, Malterer G, Erhard F, Kothe S, Friedel CC, Suffert G, Marcinowski L, Motsch N, Barth S, Beitzinger M, Lieber D, Bailer SM, Hoffmann R, Ruzsics Z, Kremmer E, Pfeffer S, Zimmer R, Koszinowski UH, Grässer F, Meister G, Haas J. Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay. Cell Host Microbe. Apr 2010. 7(4):324-334.
(» DOI: 10.1016/j.chom.2010.03.008). PDF